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Determinations of Organ Coefficient and Body Measurement in SD and Wistar Rats Aged 5 to 7 Weeks
- TIAN Yong-lu,YU Hong-jiang,ZHANG Xi-mu,LI Jun,LIU Jing-hao,BAI Hui-chen,ZHU De-sheng
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2009, 26(06):
21-25.
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Asbtract
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Objective To measure body weight,organ weight,and lengths of body,head and intestinal canal,and to calculate organ coefficient(organ weight/body weight ratio) in SD and Wistar rats aged 5 to 7 weeks.Methods The animals were fasted 12 hours and weighed,and then they were sacrificed with an intraperitoneal injection of pentobarbital sodium(45 mg/kg).First,the animals' head length,body length and tail length were measured with a ruler,and the organs were weighted and organ coefficients were calculated.And then the lengths of small intestine,cecum,ileum,and rectum,and total length of intestinal canal were also measured.Results There were very significant differences(P<0.01) in organ coefficients of heart,liver,spleen,kidney,brain,testis and ovary between the 7 weeks and 5 weeks in SD rats,and there were very significant differences(P<0.01) in organ coefficients of heart,liver,spleen,lung,kidney, thymus and brain organ between the 6,7 weeks and 5 weeks in Wistar rats.There were very significant differences(P<0.01) in the lengths of small intestine,cecum,colon,rectum of male Wistar rats between the 7 weeks and 5 weeks.There were significant differences(P<0.0) in lengths of head,body and tail of Wistar rats between the 6,7 weeks and 5 weeks.Conclusion There are significant differences in organ coefficient,the digestive tract length and body measurement in SD and Wistar rats aged 5 to 7 weeks,and there are different variations in different strains and sexes.
