Abstract: Atopic dermatitis ( AD) is a common chronic inflammatory skin disease. the incidence in children is almost to 20%, but now there is no cure for the disease,which seriously affects the healthy growth of infants and the quality of China’ s population. Therefore, it is important to elucidate the cause of AD to further guide the clinical treatment strategies and the development of drug targets. Disease models are the basis of research. Animal disease models can visually present the occurrence and development of AD, which is helpful to study the development law of AD. Because mice are highly homologous to human genome and highly fecund, they are often used as model animals for disease research. In this paper, we summarized the research on AD from CNKI and PubMed databases in recent years, model characteristics and molding methods of these AD mouse models to facilitate AD research.

Key words: atopic dermatitis (AD) , mice, research progress

摘要： 特应性皮炎(AD)是一种常见的慢性炎症性皮肤病,儿童中发病率高达 20%,目前缺乏有效的治疗措施,严 重影响婴幼儿的健康成长及我国的人口质量。 因此,对 AD 进行病因学研究,进一步指导临床治疗策略的制定及药 物靶点的开发至关重要。 动物疾病模型可以直观地呈现 AD 发生发展过程,有助于更高效地研究 AD 发展规律。 小鼠因其与人类基因组序列高度同源,繁殖力强,通常作为疾病研究的模式动物。 本文通过对近年来中国知网及 PubMed 等数据库中有关 AD 的研究内容检索查阅,就 AD 小鼠的构建方法进行总结,归纳现有 AD 小鼠造模方法和 模型特点,为 AD 研究提供参考。

关键词: 特应性皮炎, 小鼠, 研究进展