Neuromyelitis optica spectrum disease (NMOSD) is a neurological disease involving the optic

nerve, spinal cord and posterior polar region. It is an immune disease dominated by humoral immunity

and supplemented by cellular immunity. However, although there are many passive immune animal

models and a small number of active immune animal models imitating the pathogenesis of NMOSD, there

is no unified and highly imitative experimental animal model of NMOSD. Combined with the literature on

NMOSD in recent years, this paper reviews the research progress of experimental animal models of

NMOSD.

optic neuromyelitis, rats, mice, animal model, immune, AQP-4

视神经脊髓炎谱系疾病(NMOSD)是一种累及视神经、脊髓、脑后极区,以体液免疫为主、细胞免疫为辅的神

经免疫性疾病。 虽然目前模仿 NMOSD 发病机制已出现多种被动免疫型、少量主动免疫型动物模型,但目前尚无统

一的、临床高模仿性的 NMOSD 的实验动物模型制备方法。 本文结合近年来关于 NMOSD 研究的文献,就 NMOSD

的实验动物模型研究进展进行综述。

视神经脊髓炎, 大鼠, 小鼠, 动物模型, 免疫, AQP-4