Abstract: Objective To establish an animal model of seborrheic dermatitis in rats after consuming high fat diet. Method The proportion of Omega-6 and Omega-3 was studied, and the rats were fed diets with different contents for 4 weeks. The skin lipid secretion and the symptoms of depilation, scaling, red rash and papule were observed and compared among different groups. To further study the effects of different proportions and contents of high-fat foods on skin oil secretion, skin surface fungal flora, skin pathological sections and serum interleukin-4, interleukin-6 and TNF-α concentrations, and compare the skin status of rats with seborrheic dermatitis and healthy rats. Result Omega-6 to Omega-3 ratio 20 ∶ 1. Feeding a high-fat diet containing up to 31. 5% for 4 weeks resulted in abnormal secretion of lipid on the skin of rats, symptoms of hair removal, scaling, rash and papule appeared in different degrees on the skin of rats, serum interleukin-4, interleukin-6 and triglyceride concentrations increased, tumor necrosis factor decreased, and seborrheic dermatitis was successfully established. Conclusion The rat model of  seborrhoeic dermatitis was established successfully by changing the content of lipid in feed. 

Key words: seborrheic dermatitis, Omega-3, Omega-6, animal model

摘要： 目的 研究大鼠摄取高脂食物建立溢脂性皮炎病的实验动物模型。 方法 研究 Omega-6 和 Omega-3 比例、 含量不同的饲料饲喂大鼠 4 周,观察其皮肤脂质分泌及脱毛、鳞屑、红疹和丘疹的症状,比较不同组别差异。 进一 步研究不同比例和含量高脂食物对皮肤油脂分泌、病理以及血清中白介素 4、白介素 6、肿瘤坏死因子的影响,对比 患有溢脂性皮炎大鼠和对照大鼠的皮肤和生理状态。 结果 Omega-6 和 Omega-3 比例 20 ∶ 1,含量高达 31. 5%高脂 饲料饲喂大鼠 4 周导致其皮肤脂质分泌异常,大鼠皮肤上出现不同程度的脱毛、鳞屑、红疹和丘疹的症状,血清中 白介素 4、白介素 6、甘油三酯浓度升高,肿瘤坏死因子降低,显示脂溢性皮炎病成功造模。 结论 通过改变饲料内 脂质的含量,成功构建大鼠溢脂性皮炎病实验动物模型。

关键词: 溢脂性皮炎, Omega-3, Omega-6, 动物模型