Abstract: Objective To systematically analyze the basic situation of laboratory animal resources in Yunnan Province, and to provide a scientific basis for the construction of laboratory animal innovation service system in Yunnan Province. Method A questionnaire and verification were used to survey the resources and industry distribution, production and use of laboratory animals, facility area and equipment investment, and employees of 44 laboratory animal institutions licensed before June 30, 2023, in Yunnan Province. Result All 44 questionnaires were retrieved. In Yunnan Province, laboratory animal institutions are distributed in 8 prefectures, and 54. 5% of them are enterprises, among which the biomedical industry accounts for the largest proportion (47. 7%) . There are a total of 79 licenses in the province, including 51 use licenses and 28 production licenses, with Kunming accounting for 72. 2% of  the licenses. 7 categories of laboratory animals and monkey feed are produced, and the production capacities of monkey feed, mice and specific pathogen-free( SPF) grade guinea pigs are 28. 8, 5. 6 and 3. 0 times respectively of the production volumes in 2022. 13 categories of laboratory animals are used, including mice, rats, guinea pigs and rabbits. The total area of laboratory animal facilities was 186 000 m 2 , of which production facilities accounted for 66 %, and the proposed facilities accounted for 71%. The total value of instruments and equipment for animal experiments accounts for 69%. From 2021 to 2023, there is an upward trend in the cost of operating the facility. 95% of full-time laboratory animal personnel hold training record cards. Conclusion It is necessary to lead the layout of experimental animal industrialization from the government level, establish an operation mechanism for experimental animal innovation and development in Yunnan Province, and enhance the ability of laboratory animals to serve scientific and technological innovation.

Key words: laboratory animals, resource, facilities and equipment, industrialization, Yunnan province

摘要： 目的 系统分析云南省实验动物资源基本状况,为云南省实验动物创新服务体系建设提供支撑。 方法 采 用问卷及核查方式,对云南省 2023 年 6 月 30 日前取得许可证的 44 家实验动物机构的资源及行业分布、实验动物 生产和使用情况、设施面积及设备投入、从业人员情况开展普查。 结果 收回全部问卷 44 份。 云南省实验动物机 构分布在 8 个州市,54. 5% 为企业,在生物医药行业占比最多( 47. 7%) 。 全省共 79 个许可证,使用许可证 51 个, 生产许可证 28 个,昆明市许可证占 72. 2%。 生产 7 类实验动物和猴饲料,猴饲料、小鼠和 SPF 级豚鼠的生产能力 分别为 2022 年产量的 28. 8、5. 6 和 3. 0 倍。 使用小鼠、大鼠、豚鼠、兔等 13 类实验动物。 实验动物设施总面积为 186 000 m 2 ,其中生产设施占 66%,而拟建的使用设施占 71%。 动物实验的仪器设备总价值占 69%。 2021 年至 2023 年,设施运行经费呈上升趋势。 专职从事实验动物人员中 95% 持培训记录卡。 结论 应从政府层面引领实 验动物产业化布局,建立云南省实验动物创新发展的运行机制,提升实验动物服务科技创新的能力。

关键词: 实验动物, 资源, 设施设备, 产业, 云南省