Abstract: Depression has received widespread attention from the medical community due to its increasing
incidence year by year. The factors of depression are extremely complex, so the construction of
depression models has become a key step when conducting related experiments. This paper mainly
introduces the construction method of common mouse depression models, such as chronic unpredictable
mild stimulus model, special drug-induced depression model, early life stress model, etc. , and related
behavioural experiments to assess the degree of depression, such as forced swimming experiment, sucrose
preference experiment, splashing experiment, etc. , which provide relevant researchers with experimental
ideas and method.

Key words: depression, animal models, behavioral assessment

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