Recurrent aphthous ulcer is the most common oral mucosal disease. Because of its unknown etiology, the treatment is mainly to relieve pain, reduce the number of recurrences, and prolong the interval period. The establishment of a good animal model is essential to study the etiology and treatment of recurrent aphthous ulcers. At present, the method for the establishment of recurrent aphthous ulcers include mechanicalmethod, This article reviews several common methods for establishing models and evaluating the results of recurrent aphthous ulcers, and compares the advantages and disadvantages of the models. The aim is to provide a basis for researchers to select models for studying the pathogenesis and drug treatment of recurrent aphthous ulcers.

recurrent aphthous ulcer, rats, animal model

复发性阿弗他溃疡是最常见的口腔黏膜疾病,其发病机制及病因尚未被阐明,同时治疗常以缓解疼痛,减少复发次数,延长间隙期为主。 因此建立一个良好的动物模型对研究复发性阿弗他溃疡的病因和治疗手段至关重要。 本文综述了复发性阿弗他溃疡的几种常见的模型建立方法及结果评价,同时比较了模型的优劣,旨在为科研人员研究复发性阿弗他溃疡的发病机制及药物治疗时,提供建模的选择依据。

复发性阿弗他溃疡, 大鼠, 动物模型