Abstract: Objective To facilitate the open sharing of Nifdc: SD, Nifdc: Wistar, F344/NSlcNifdc, and BN/ SNslcNifdc rats preserved in the National Rodent Laboratory Animal Resources Center, this study is conducted.Methods　Blood physiological and biochemical values of four different types of rats of different ages and genders from the foundation stock of National Rodent Laboratory Animal Resources Center were measured.Results　The average values and normal reference ranges of blood physiological and biochemical indexes were obtained for rats of different genders at 4 weeks and 8 weeks old. Through comparison, it was found that among the 23 blood physiological indexes of Nifdc: SD, Nifdc: Wistar, F344/NSlcNifdc, and BN/SNslcNifdc rat strains, only 2, 3, 3, and 8 indexes were not significantly affected by age and gender factors, respectively. Among the 9 blood biochemical indexes, only the UREA indexes of F344/NSlcNifdc rats and ALT, AST, and UREA indexes of BN/SNslcNifdc rats, which were not significantly affected by age and gender factors. Conclusion　This study provided biological background data for the rat foundation stocks in the National Rodent Laboratory Animal Resources Center, in addition, gender and age factors could have an impact on the blood physiology and biochemical indicators of rats. 

Key words: rats, biological characteristics, blood physiological indexes, blood biochemical indexes

摘要： 目的　为推动国家啮齿类实验动物资源库中保存的Nifdc:SD、Nifdc:Wistar、F344/NSlcNifdc和BN/ SsNSlcNifdc 4种大鼠资源的开放共享,开展本研究。方法　对来自于资源库基础群的4周龄和8周龄不同性别的 4种大鼠的血液生理和血液生化指标数据进行了测定。结果　取得了4周龄和8周龄不同性别大鼠的血液生理和 生化指标的平均值及正常参考范围。通过比较发现,Nifdc:SD、Nifdc:Wistar、F344/NSlcNifdc和BN/SsNSlcNifdc 4 种大鼠,在23项血液生理指标中,分别仅有2、3、3和8项指标未受到年龄和性别因素的显著影响。在9项血液生 化指标中仅F344/NSlcNifdc大鼠的UREA指标和BN/SsNSlcNifdc大鼠的ALT、AST和UREA等3项指标未受到年 龄和性别因素的显著影响。结论　以上结果为资源库大鼠基础群提供了生物学特性背景数据,其中性别和年龄因 素会对大鼠血液生理和生化指标造成影响。

关键词: 大鼠, 生物学特性, 血液生理指标, 血液生化指标