Abstract: Hyperuricemia nephropathy ( HN ) is a secondary kidney injury, mostly caused by the imbalance of uric acid production and excretion,resulting in hyperuricemia ( HUA) and thus triggering HN, whose main manifestations are renal inflammation, renal tubular injury, and renal interstitial fibrosis, which can easily lead to the functional damage of multiple organs if not intervened in a timely manner. As the prevalence of HN increases, the search for efficient and safe treatment options has become an urgent clinical task. However, at this stage, there is limited understanding of the mechanisms and therapeutic method of NH, and a well-recognized animal model has not yet been established. Therefore, in this paper, we systematically sorted out the commonly used model construction method from the aspects of animal selection, modeling method and effect evaluation, and sought to construct an efficient and stable animal model of HN.

Key words: hyperuricemicnephropathy, uric acid, hyperuricemia, animal models, kidney injury

摘要： 高尿酸血症肾病( HN)是一种继发性的肾损伤,多因尿酸生成-排泄失衡致高尿酸血症( HUA) 从而诱发 HN, 其主要表现为肾炎症、肾小管损伤以及肾间质纤维化,若不及时干预易累及多种脏器功能损伤。 随着 HN 的患病 率增加,寻求高效且安全的治疗方案成为临床较为紧急的任务。 但现阶段对 HN 的发生机制以及治疗方法了解有 限,在基础研究中尚未建立公认的动物模型。 因此本文从动物选择、造模方法、效果评价等方面入手,系统地梳理 了常用模型构建方法,并寻求构建高效稳定的 HN 动物模型。

关键词: 高尿酸血症肾病, 尿酸, 高尿酸血症, 动物模型, 肾损伤