Abstract: Abstract: Objective To Compare four methods of developing hyperlipidemia in Mongolian gerbils． Method The gerbils in the experimental groups were fed respectively with four high-fat fodders with varying amounts of cholesterol，lard and cholate． The gerbils in the control group were fed with normal fodder． Serum levels of triglyceride ( TG ) ，total cholesterol ( TC ) ， low-density lipoprotein cholesterol ( LDL-C ) and high-density lipoprotein cholesterol ( HDL-C) in the gerbils in all the groups were measured at the 0th，30th，60th day． Animals were sacrificed and the morphological changes of the liver were examined by histopathology． Result Serum levels of TC，LDL-C and HDL-C in gerbils of the experimental group were significantly higher than those in gerbils of the control group during the 30th，6 0th days，with a remarkable increase in serum TC level in particular， and increase of serum LDL-C were obviously bigger than the increase of serum HDL-C． There have been varying degrees of fatty liver in the experimental groups． Conclusion Four high-fat fodders can all cause hyperlipidemia in the gerbils．

Key words: Mongolian gerbil, hyperlipidemia, fatty liver

摘要： 摘要: 目的比较长爪沙鼠高脂血症模型的4 种造模方法。方法选取用于复制大鼠高脂血症动物模型的4 种配 方饲料，饲喂长爪沙鼠60 d，分别在0 d、30 d、60 d 空腹12 h 后眼眶取血，测定血清中甘油三酯( TG) 、总胆固醇 ( TC) 、高密度脂蛋白胆固醇( HDL-C) 和低密度脂蛋白胆固醇( LDL-C) 的含量，观察肝组织的形态学变化。结果 4 种高脂配方饲料在30 d、60 d 均使长爪沙鼠血清的TC、HDL-C、LDL-C 的值明显高于对照组，以TC 升高最为明 显，并且LDL-C 的增加幅度明显大于HDL-C 的增加，并出现不同程度的脂肪肝。结论4 种高脂配方饲料均可复 制长爪沙鼠高脂血症模型。

关键词: 长爪沙鼠, 高脂血症, 脂肪肝