Abstract: To observe effects of therapeutic dose of itopride hydrochloride on rat animal model with acid reflux esophagitis.METHODS To study the effect of therapeutic dose of itopride hydrochloride on intestinal propulsion and pathological moriphology of esophagus mucosa with acid reflux esophagitis induced by pyloric partial ligation and cardiac sphincter dissection .RESULT The itopride hydrochloride has significant effect on intestinal propulsion function and relieve esophagus mucosa injury of rat animal model.CONCLUSION The therapeutic dose of itopride hydrochloride has obvious curative effect on acid reflux esophagitis rat animal.

Key words: font-size: 10.5pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 仿宋_GB2312" lang="EN-US">Itopride Hydrochloride, acid reflux esophagitis, animal model.

摘要： 目的探讨盐酸伊托必利临床常用剂量对大鼠酸性反流性食管炎模型的作用。方法采用不完全结扎幽门 +食管下括约肌切开术制备大鼠酸性反流性食管炎模型，观察盐酸伊托必利临床常用剂量对大鼠酸性反流性食管 炎模型小肠推进及食管黏膜病理形态的影响。结果盐酸伊托必利能明显提高酸性反流性食管炎模型大鼠的小 肠推进功能，明显减轻模型大鼠食管黏膜的损伤。结论盐酸伊托必利临床常用剂量对大鼠酸性反流性食管炎模 型有明显的治疗作用。

关键词: 盐酸伊托必利, 大鼠, 酸性反流性食管炎, 动物模型