Abstract: [Abstract] Objective To observe routine pathological changes of the pancreas, kidney, testis and ovary in spontaneous diabetic mice. Methods C57BL/KsJ- db/db mice with blood glucose over 10.1 mmol/L at 2, 7 and 12 month entered this study, after sacrificed, their organs pancreas, kidney, testis and ovary were soaked in 10% formalin for HE coloration and general pathological section. Results At 7 or 12 month, the pancreas tissues had lymphocyte infiltration, partial pancreas islets size increase and condulet hyperplasy ectasia; the kidney showed partial glomerular cell numbers increase, mesangial cell hyperplasy and basilar membrane thickening; the ovary was small with less egg follicle and missing corepus luteum; the testis was weak in spermatozoa genesis. Conclusion Some pathological changes of pancreas, kidney, testis and ovary may be observed in the C57BL/KsJ- db/db mice of spontaneous diabetes.

Key words: Pathological Changes, Diabetes ;Mice, Pancreas, Kidney, Testis, Ovary

摘要： 目的观察自发性糖尿病C57BL／K8J—db／db小鼠胰腺、肾脏、睾丸和卵巢的常规病理变化。方法取血糖高 于10．1 mmoL／L的2、7、12月龄db／db纯合仔小鼠，摘眼球放血后取胰腺、肾、睾丸、卵巢放入Io％福尔马林溶液中， HE染色。常规病理切片。结果7、12月龄胰腺见淋巴细胞浸澜，部分胰岛体积较大，小导管样病变有增生扩张及 潴溜；小鼠肾脏见部分肾小球细胞数增多，系膜细胞增生。系膜基质增多；卵巢较小，卵泡较少，未见黄体；睾丸生精 功能弱。结论c57BL／KsJ．db／db小鼠的自发性糖尿病会在一定程度上出现胰腺、肾脏、睾丸和卵巢等脏器发生病 理改变。

关键词: 病理改变, 糖尿病, 小鼠, 胰腺, 肾脏, 睾丸, 卵巢