Abstract: Objective To compare the anesthetic effect of pentobarbitol sodium made by different factory on rats and rabbits.Methods Pentobarbitol sodium from chemical reagent factory of Foshan,Shanghai Xingzhi chemical reagent factory, Shanghai chemical reagent factory of Chinese medicine corporation(abbreviated as P_(fo),P_(shang),P_(zhong) individually) were made into solution,which were administrated to rats by celiac injection at the dose of 45 mg/kg and rabbits by vein injection at the dose of 30 mg/kg.Each kind of drug was administrated to 20 rats and 20 rabbits with half male and half female individually.The acting time,acting duration and the general state of anesthesia were recorded.Results The acting time(minute) of P_(fo),P_(shang),P_(zhong) on rats was 3.8,6.6 and 4.5 individually,acting duration was 152,107 and 126,the general state of anesthesia was P_(fo) and P_(zhong) were more ideal than P_(shang),The acting time(minute) of P_(fo), P_(shang),P_(zhong) on rabbits was 0,0～1and 0 individually,acting duration was 148,89 and 138,the general state of anesthesia was P_(fo) and P_(zhong) were more ideal than P_(shang).Conclusion Anesthetic effect of pentobarbitol sodium from different factory on rats and rabbits is P_(fo) were more ideal than P_(zhong),P_(zhong) were more ideal than P_(shang).

Key words: Pentobarbitol sodium, Anesthesia, Comparison

摘要： 目的比较不同厂家的戊巴比妥钠对大鼠和家兔的麻醉效果。方法将佛山市化工实验厂、上海行知化工厂和中国医药集团上海化学试剂公司的戊巴比妥钠粉剂(分别简称Pfo、Pshang和Pzhong)配制成溶液,分别对大鼠腹腔注射(45 mg/kg)和家兔耳缘静脉注射(30 mg/kg)进行麻醉,其中每组药物大鼠20只,家兔20只,雌雄各半。记录实验中动物麻醉起效时间、麻醉持续时间和动物麻醉一般情况。结果Pfo、Pshang和Pzhong对大鼠麻醉起效时间分别为3.8、6.6和4.5 min;麻醉维持时间为152、107和126 min,麻醉一般情况,Pfo和Pzhong较Pshang理想。对家兔麻醉的起效时间分别为0、0~1和0 min;麻醉维持时间为148、89和138 min,麻醉一般情况,Pfo和Pzhong较Pshang理想。结论戊巴比妥钠对大鼠和家兔的麻醉效果比较,Pfo优于Pzhong,Pzhong优于Pshang。

关键词: 戊巴比妥钠, 麻醉, 效果比较SD大鼠, Wistar大鼠, ICR小鼠