关键词:  , BALB / c 小鼠, 围手术期, 镇痛, 美洛昔康, 动物福利

Abstract: Objective To reduce perioperative pain in mice during tumor resection, ensure animal welfare and the accuracy of research data, the perioperative analgesic effect of meloxicam on tumorbearing mice were explored in this study. Method All BALB / c mice were anesthetized with Zoletil and Dexmedetomidine, and then divided into the control group ( group A) and meloxicam injection group ( group B) . The mouse grimace scale and pain behavior frequency were evaluated to assess the pain level of mice, and the body weight and the histopathology of the organs were observed to test the safety of meloxicam. Result The result showed that compared with group A, the anesthesia induction time and the recovery time in group B were shorter, while the recovery time in group B was significantly longer (P<0. 01) ; the mouse grimace scale and pain behavior frequency in group B were significantly lower than group A within the first 3 days; the main organs and intestinal tissues of all mice had no histopathological lesions, the weight of mice showed no significant difference, and all the mice in group B were survived. Conclusion The result suggested that meloxicam combined Zoletil and Dexmedetomidine anesthesia regimen could shorten the induction of anesthesia and slowly lengthen the recovery time of mice bearing with tumors, significantly reduce their perioperative pain, and be safe.

Key words: BALB / c mice, perioperative period, analgesia, meloxicam, animal welfare