关键词: 糖尿病肾病, 动物模型, 转基因小鼠

Abstract: Diabetic nephropathy ( DN) is the most common complication of diabetes mellitus, and the leading cause of death in patients with end-stage renal disease and diabetes mellitus. At present, DN development is prevented mainly by controlling blood glucose and blood lipids and lowering blood pressure. Because of the complicated etiology of DN , thecurrenttreatmentmethod failed toreach thedesired goal.Therefore , new interventions or treatments are urgently needed to delay the progression of diabeticnephropathy. Animal models are of great value in analyzing the pathogenesis of diseases and testing new therapies, and ideal animal models are capable of investigating the pathogenesis of diabetic nephropathy , determining drug targetsand verifying new therapeutic strategies. However, there is a lack of animal models that can simulate the main characteristics of human DN in the field of DN research at present. In this paper , we discussed the progress , limitations and improvement of DN animal models in order to replicate ideal animal models similar to the main clinical and molecular phenotypes of human DN in the future.

Key words: Diabetic nephropathy , animal model, transgenic mice