关键词: 无菌动物, 肠道菌群, 动物模型, 斑马鱼, 鼠

Abstract: The intestinal flora is a large and complex micro-ecological system, and it is also a key factor in maintaining the dynamic balance of the body. This system is now becoming a new target for disease prevention , diagnosisand treatment. Sterile animals provide an ideal animal model for the study of interactions between host and microorganisms and between microorganisms.By inoculating sterile animals with specific single ormultiple microorganisms , we can see their significance in the focused study of intestinal flora. In this paper , the characteristics and corresponding research applications of several commonly used sterile animals as experimental models were reviewed , and the application value of aseptic animals as model animals in the study of intestinal flora was analyzed.

Key words: sterile animals, intestinal flora , animal model, zebrafish , mouse