实验动物科学 ›› 2024, Vol. 41 ›› Issue (4): 92-96.DOI: 10.3969/j.issn.1006-6179.2024.04.015

• 综述 • 上一篇    

精神障碍模式鼠的行为学测验原理与方法

  

  1. (温州医科大学精神医学学院,温州 325000)
  • 收稿日期:2023-01-16 出版日期:2024-08-28 发布日期:2024-08-28
  • 通讯作者: 王 琦( 1986—) ,男,博士,讲师,研究方向为精神障碍的神经机制,E-mail: wangqi1986525@ 126. com; wangqi@ wmu. edu. cn。
  • 作者简介:万伊甸( 2002—) ,女,本科生在读,专业为精神病与精神卫生学,E-mail: w956270979@ 163. com。 李雨亭( 2002—) ,女,本科生在读,专业为精神病与精神卫生学,E-mail: lyting1121@ 163. com。

Principles and Methods for Behavioral Tests of Mental Disorder-like Rodents

  1. ( School of Mental Health, Wenzhou Medical University, Wenzhou 325000, China)
  • Received:2023-01-16 Online:2024-08-28 Published:2024-08-28

摘要:

精神障碍指由于大脑机能紊乱,导致患者精神活动(情感、认知、意志等) 产生障碍。 内隐的精神障碍常伴随
外显的行为异常。 构建精神障碍模式动物对探究精神障碍的发病机制至关重要,而用动物行为学的实验方法测量
精神障碍模式动物的行为表型,对评价精神障碍相关研究的有效性具有重要意义。 因此,本文基于精神障碍模式
鼠的相关研究,总结常见精神障碍(抑郁障碍、焦虑障碍、双相情感障碍、孤独症谱系障碍、注意缺陷多动障碍、创伤
后应激障碍、强迫症)的行为学测验原理与方法,以期对精神病学的基础研究提供参考。

关键词:

Abstract: Mental disorders refer to the disorders in the mental activity ( affection, cognition, and
volition, etc) of patients, which are caused by the brain dysfunction. Implicit mental disorders are
usually accompanied by explicit abnormal behaviors. Building mental disorder-like animals is vital for
exploring the pathogenesis of mental disorders, and is meaningful for evaluating the validity of the
researches on mental disorders. Therefore, based on previous studies about mental disorder-like rodents,
we summarized the principles and method for behavioral tests of some mental disorders ( depression,
anxiety, bipolar disorder, autism spectrum disorder, attention deficit hyperactivity disorder, posttraumatic stress disorder, obsessive-compulsive disorder ) , expecting to provide a reference for the fundamental researches of psychiatry.

Key words: mental disorder, animal model, ethology, behavior

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