Laboratory Animal Science

Establishment of a Model of Transplantation of Human Lung Adenocarcimoma with High Expression of CEA in Nude Mice

Xu Jinj ie Shen Jian Shen Zhongying Department of Onco─pathology Shantou University Medical College

1995, 12(03): 0-0.

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A model of the transplantation of human lung adenocarcinoma with highexpression of CEA in nude mice(LAX-91)was established by the direct transplantation ofa surgical specimen from a patient with well-differentiated Iung cancer subcutaneously inthe NIH nude mice.The transplanted tumor had been passed on for more than two yearsthrough 32 passages.The LAX-91 tumor had short incubation Periods and grew quitesteadily.The rate of success was 100%. Pathohistological obseryation of the transplantedtumor in each generation showed that it had maintained the structure of the original human tumor and had the function of secretion.Chromosomal analysis revealed that the tumor cells had the characteristics of the human malignant tumor.The results of serum CEA con-tent determination for various times indicated that the LAX-91 tumor had possessed the biological claracteristics of secreting CEA stably and highly. The establishment of such a transplanted tumor model provides a useful method for the further studying of the relations between human Iung cancer and CEA.

Study of the method of establishing human brain tumor─nude mice model with tumor tissue

LanQing Huang Qiang

1995, 12(03): 0-0.

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Three nude mice solide tumor models bearing human brain tumors wereestablished with tumor tissue from the Patients,the initial succeesful transplantation rate of that method was 42.8%.The transplanted tumors kept the nature of initial tumors on qual-ily,blood supply tissue structure,growth speciality and so on.The method with tumor tis-sue is better than that with cell line , because of its directness,quickness and steadiness.The high rate of success is due to quick inoculation,With long term observation and purgative condition.

Virus Infection Monitoring On Macace Mulatta In Guangxi Xianhu Experimental Animal Breeding Farm

Li Jin Deng Pinjuan Guangxi Training Institute of Hygiene Management

1995, 12(03): 0-0.

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The monitoring results of virus infection among 3 generations of M.mulattafor eight years in Guangxi Xianhu experimental animdal breeding farm is reported in thispaper. Infection rate of B virus and SCMV drops from 100% for parents to 0%for theirfirst and scond generations.Discussion is also made on systematicdtl on breediong farm.

The Measurement of Parameters in ultrasound Cardiofram of Adult Healthy Canine

Yang Liyan Feng Yunling Zhong Pei Cardiovascular section of Medicine,BeiJing Medical Unirersity 100083[

1995, 12(03): 0-0.

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This psper reports the measurement of parameters in M─Mode,Two─ dimensional and ultrasound Doppler cardiograms of adult healthy canines. Effects of sex and body weifht on the 33 parameters are analysd.The purpese of this study is to pro-vide normal parameters for the in vestigation of disease models of the canhe.The result shows that the effecf of sex difference is not significant on the anatomicparameters,but significent on the hemoclynamicparameters and the main parameters ap-pear relative with the differences of the body weifht.It is better stability on the parametersin anatomic morphology than hemodynamics.

Advances in the Research on Animal Models of Human Hepatitis

Li Jingjing Chen Qiansheng Guangdong Laboratory Animal Monitoring Institute [

1995, 12(03): 0-0.

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Progress in humam disease research relies on the establishment of animalmodels to a certain degree.Experimental amimal models have played an important role inhepatitis research especeally in pathogenesis studies,understanding routes of viral dissemi-nation and mechanism of viral replication as well as vaccine testing.The recent advanecs inthis field are reviewed in the article.

Update Progress in Preparation of Virus-vectored Vaccines Their Immunity

Zhang Deli

1995, 12(03): 0-0.

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The update important advances,existing questionis,developing countermeasures application prospects of virus-vectored vaccines have been critically re-viewed from the following three aspects:(1)Nonreplicating fowlpoxvirus,canarypoxvirus,vaccinia cirus of human adenovirus-vectored live vaccines their immunity;(2)Live adenovirus-vectored vaccines their immunity; and(3) Bacularvirus-vectored subunit vac-cines tyeir immunity.It is an update trend in genetically-engineered vaccines that the virus-vectored vaccines have come of age.

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