Innovation and Development of Laboratory Animal Science and Technology:Core Progress and Significant Achievements of Key Special Projects During the 14th Five-Year Plan Period

doi:10.3969/ j. issn.1006-6179.2026.04.001

Laboratory Animal Science ›› 2026, Vol. 43 ›› Issue (4): 1-5.DOI: 10.3969/ j. issn.1006-6179.2026.04.001

(1.National Institutes for Drug Control, Beijing 102629,China)(2.Harbin Veterinary Research Institute, Chinese Academy of
Agricultural Sciences, Harbin 150069, China)(3.Jiangsu JICUI Pharmaceutical Biotechnology Co., Ltd., Nanjing 211800,China)
(4.Beijing Administration Office of Laboratory Animal, Beijing 101117,China)(5.Naval Military Medical University,
Shanghai 200433,China)(6.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201,China)

Received:2026-05-26 Online:2026-08-28 Published:2026-09-07

实验动物科技创新发展:“十四五”重点专项核心进展与重要成果

(1.中国药品检定研究院,北京　102629)(2.中国农业科学院哈尔滨兽医研究所,哈尔滨　150069)
(3.江苏集萃药康生物科技有限公司,南京　211800)(4.北京市实验动物管理办公室,北京　101117)
(5.海军军医大学,上海　200433)(6.中国科学院昆明动物研究所,昆明　650201)

通讯作者: 吕龙宝(1974—),男,博士,教授,研究方向为实验动物资源开发、遗传与表型。E-mail:lvlongbao@mail.kiz.ac.cn。
作者简介:贺争鸣(1957—),男,博士,研究员,研究方向为实验动物资源建设与管理。E-mail: zhengminghe57@163.com。
基金资助:
第四次实验动物资源调查与发展趋势及政策研究(WT202512)。

Abstract

Abstract: Laboratory animal resources and their standardized system constitute the core foundation supporting life science innovation and the development of the biomedical industry. To enhance China’s independent support capability and international competitiveness in experimental animal science and technology, during the “14th Five-Year Plan” period, laboratory animals were included in the national key research and development plan for the first time, systematically carrying out research on resource creation, model construction, detection technology, and support systems. This article focuses on the implementation of the special project, adopting a full-chain deployment and integrated implementation approach,and revolves around the two major directions of “resource creation and application support”. It systematically reviews the implementation progress and core achievements of 32 projects and 107 topics. The results show that China has added 22 standardized varieties, with an increase of 84.62% in species resources; constructed more than 200 precision models for major diseases, made breakthroughs in 129 key detection technologies, developed the first set of intelligent specialized equipment, and formed an independently controllable laboratory animal technology and resource system. The research conclusion indicates that China’s experimental animal science and technology have achieved a leap from decentralized support to systematic layout, providing an important foundation for the “15th Five-Year Plan” to move towards parallel and leading development, and supporting original innovation in biomedicine.

Key words: laboratory animal, key special projects, resource creation, disease models, standardization

摘要： 实验动物资源及其标准化体系是支撑生命科学创新与生物医药产业发展的核心基础。为提升我国实验动物科技自主保障能力与国际竞争力,“十四五”期间我国首次将实验动物纳入国家重点研发计划专项,系统开展资源创制、模型构建、检测技术与支撑体系研究。本文以专项实施为对象,采用全链条部署、一体化实施思路,围绕“资源创制与应用保障”两大方向,系统梳理了32个项目、107个课题的实施进展与核心成果。结果表明:我国新增标准化品种22个,物种资源增幅达84.62%;构建重大疾病精准模型200余种,突破检测关键技术129项,研制出首套智能化专用装备,形成自主可控的实验动物技术与资源体系。研究结论显示,我国实验动物科技已实现从分散支持到系统布局的跨越,为 “十五五” 迈向并跑、领跑,支撑生物医药原始创新提供了重要基础。

关键词: 实验动物, 重点专项, 资源创制, 疾病模型, 标准化

CLC Number:

Q95-3

He Zhengming, Chen Hongyan, Gao Xiang, Li Genping, Cui Shufang, Lyu Longbao. Innovation and Development of Laboratory Animal Science and Technology:Core Progress and Significant Achievements of Key Special Projects During the 14th Five-Year Plan Period[J]. Laboratory Animal Science, 2026, 43(4): 1-5.

贺争鸣, 陈洪岩, 高　翔, 李根平, 崔淑芳, 吕龙宝. 实验动物科技创新发展:“十四五”重点专项核心进展与重要成果[J]. 实验动物科学, 2026, 43(4): 1-5.

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