SNP Genotyping Technologies and its Application in Genetic Monitoring in Rats

doi:10. 3969 / j. issn. 1006-6179. 2024. 01. 019

Laboratory Animal Science ›› 2024, Vol. 41 ›› Issue (1): 104-107.DOI: 10. 3969 / j. issn. 1006-6179. 2024. 01. 019

(National Rodent Laboratory Animal Resources Center, Institute for Laboratory Animal Resources, National Institutes for Food and Drug Control (NIFDC) , Beijing 102629, China)

Received:2022-09-13 Online:2024-02-28 Published:2024-03-15

SNP 分型检测技术及其在大鼠遗传检测中的应用

(中国食品药品检定研究院实验动物资源研究所国家啮齿类实验动物资源库,北京 102629)

通讯作者: 岳秉飞( 1960—) ,男,博士,研究员。研究方向为动物遗传学,E-mail:y6784@ 126. com。
作者简介:李欢( 1996—) ,女,研究生,研究方向为免疫遗传学,E-mail:13834661946@ 163. com。
基金资助:
国家重点研发计划( 2021YFF0703200)

Abstract

Abstract: Single nucleotide polymorphism ( SNP ) is the third generation of molecular genetic markers. Due to its universality, genetic stability, dimorphism and easy automatic typing, SNP has become an important genetic marker in the field of experimental animal genetic detection. Therefore, this paper briefly summarizes the characteristics and types of SNP, and focuses on several SNP typing techniques and the application of SNP in genetic detection in rats.

Key words: rat, single nucleotide polymorphism( SNP) , SNP genotyping, genetic monitoring

摘要： 单核苷酸多态性( SNP)是第三代分子遗传标记,由于其广泛性、遗传稳定性、二态性及易于自动化分型的特点,成为当前实验动物遗传检测领域中重要研究的遗传标记。本文概述了 SNP 概念及特点,重点阐述不同种类SNP 分型技术,并对该技术在大鼠遗传检测研究中的应用进行回顾和展望。

关键词: 大鼠, 单核苷酸多态性( SNP) , SNP 基因分型, 遗传质量检测

CLC Number:

Q95-3

LI Huan, YUE Bingfei. SNP Genotyping Technologies and its Application in Genetic Monitoring in Rats[J]. Laboratory Animal Science, 2024, 41(1): 104-107.

李欢, 岳秉飞. SNP 分型检测技术及其在大鼠遗传检测中的应用[J]. 实验动物科学, 2024, 41(1): 104-107.

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