Abstract: Beagles are one of the most commonly used laboratory animals in scientific activities. Due to the stable biological properties, they are being used in many fields of medical disciplines. Beagles are recognized as the most ideal and standard laboratory dogs by experts in medicine and biology because of the consistency in their organ functions, and the well developed circulation system. Meanwhile, they are preferred in safety evaluation and widely used in drug and vaccine industry, as well as in zoonosis studies. This article discusses the application of SPF beagles in life science and provides new ideas for promoting the establishment of SPF beagle models and their research in basic medicine and other fields.

Key words: Beagle dogs, animal disease model, research on canine diseases, zoonosis

摘要： 比格犬作为科学研究工作中常用的实验动物之一,具有生物学性能稳定的特点,适用于医学各学科的研究。比格犬器官功能一致,血液循环系统发达,差异性小,是医学界和生物学界公认的最标准、最理想的实验用犬,也是安全评价的首选犬种,在药品、疫苗开发及人畜共患病的研究中得到广泛应用。 本文讨论了 SPF 级比格犬在生命科学中相关的应用,为推进 SPF 级比格犬模型的建立以及在基础医学等领域的研究提供新的思路。

关键词: SPF 级比格犬, 动物疾病模型, 犬病的研究, 人畜共患病