Abstract: Abstract: Objective To study the antipyretic effects of Ganmaoshuangjie granules. Method Rat dry yeast model and rabbit bacterial endotoxin model were used, high, medium and low doses compound of Ganmaoshuangjie granules were given. To observe the effect of cold biolysis granules on the body temperature of febrile model, the intensity of heat release was investigated. Result The high dosage group ( 1. 7 g extract powder / kg ) of Ganmaoshuangjie granules was able to significantly inhibit the elevated temperature of the dry yeast model, and cooling rate of about 0. 7 ℃ . However, the effect of the dose group on the hypothermia of bacterial endotoxin model was not obvious. Conclusion The Ganmaoshuangjie granules has a certain thermal effect on the temperature rise caused by ulceration and so on.

Key words: Key words:Ganmaoshuangjie granules, dry yeast, bacterial endotoxin, antipyretic

摘要： 摘要:目的 研究感冒双解颗粒解热作用。 方法 采用大鼠干酵母和家兔细菌内毒素解热模型,给予高、中、低剂量的感冒双解颗粒浸膏粉,观察感冒双解颗粒对发热模型动物体温的影响,考察解热作用强度及时程。 结果 感冒双解颗粒浸膏粉高剂量组(1. 7 g 浸膏粉 / kg)在给药后 1. 5 ~ 4 h 能明显抑制干酵母模型大鼠体温升高,降温幅度约为 0. 7 ℃ ,而各剂量组对细菌内毒素模型家兔的体温升高抑制作用不明显。 结论 感冒双解颗粒对溃烂等炎症引起的体温升高具有一定的解热作用。

关键词: 关键词:感冒双解颗粒, 干酵母, 细菌内毒素, 解热