Abstract: Objective To conduct pathological examination on 400 rodent laboratory animals submitted in May 2018, and make reasonable suggestions for the management of laboratory animals based on the test result. Method We collected hearts, livers, kidneys, lungs, spleens and intestinal tracts of 400 laboratory rats. Then we made these organs into paraffin sections or frozen sections. After HE staining, PAS staining or oil red O staining, these sections were placed under optical microscope to collect digital images and record the result. Result A few cases of rats, mice and guinea pigs showed hepatocellular swelling, focal inflammatory cell infiltration in lungs and hearts, and coccidia infected in intestinum crassum; no visible pathological changes in golden hamsters and hamsters. Conclusion The laboratory animals in this pathological examination are basically in a healthy state. A few animals need to be strengthened and improved the feeding and management conditions to ensure the laboratory animals meet the standards.

Key words: laboratory animals, pathological examination, pathological changes

摘要： 目的 2018年5月本实验室对北京地区22家实验动物机构送检的400只啮齿类实验动物进行病理检测。根据检测结果对实验动物的饲养管理提出合理建议。方法 采取心脏、肝脏、肾脏、肺脏、脾脏、大肠、小肠，制成石蜡切片或冰冻切片，经H.E.染色、PAS染色或油红O染色后置于光学显微镜观察，采集数码图像，记录结果。结果大鼠、小鼠、豚鼠有少数病例表现为肝细胞肿胀，肺脏、心脏局灶性炎性细胞浸润，大肠出现疑似球虫感染的病变；地鼠组织脏器均未见明显异常。结论 本次病理学抽检中的实验动物基本为健康状态，但需要加强和改善饲养管理条件。

关键词: 实验动物, 病理检测, 病变