Abstract: Abstract: Objective To observe the effect of Vitamin A on the islet fibrosis in type 2 diabetes mellitus ( T2DM) animal model of GK ( Goto-Kakizaki) rat． Method After administration of Vitamin A for 2 weeks; and the changes of islet fibrotic area were recorded． 5 μm serial paraffin sections of 4 months old GK rat pancreas were obtained and stained by H＆E and Masson staining． Ｒesult Masson staining showed that the area of islet fibrosis staining in GK rats were significantly decreased after administration of Vitamin A compared with control group ( 44. 46 ± 16. 98 vs． 60. 22 ± 31. 47 μm2 ) ． Conclusion Our study indicated that Vitamin A could significantly decrease islet fibrosis in GK rat．

Key words: <p>type 2 diabetes mellitus, islet fibrosis proliferation, Vitamin A, Goto-Kakizaki rat</p>

摘要： 摘要: 目的观察维生素A 对2 型糖尿病( T2DM) 大鼠胰岛纤维增生的影响。方法维生素A 补充2 周后，将GK大鼠胰腺石蜡切片行HE 和Masson 染色，观察胰岛纤维化区域变化。结果补充维生素A 组GK ( Goto-Kakizaki)大鼠胰岛纤维增生区域明显减少。结论外源性给予维生素A 能显著减少T2DM 胰岛纤维增生。

关键词: <p>2 型糖尿病, 胰岛纤维增生, 维生素A, GK 大鼠</p>