Abstract: Abstract: Minipigs are ideal animals for diabetes mellitus ( DM) research for its similarities with human beings on metabolism． However，during the long-term selection as domestic animals，pigs have developed the features resisted to suffer from DM． We have screened 245 boars and sows of Bama minipigs with fasting blood glucose ( FBG) ，and a high FBG pregnant pig was found． 11 piglets ( 10 survived) were born from the pig and as founders to selecting breeding． After 2 generations selection with susceptibilities to diet-induced type 2 DM，the inducing period from 7 months shortened to 6 months． It is speculated that a new line of Bama minipgs susceptible to dietinduced DM will be developed in the future．

Key words: minipig, type 2 diabetes mellitus, Bama minipig, genetic selection

摘要： 摘要: 由于小型猪代谢机制与人类十分相似，使其成为糖尿病研究的理想动物模型。然而在作为家畜的长期选育 过程中，小型猪获得了抵抗致糖尿病因素的特性。本实验室经过对245 头成年巴马小型猪的空腹血糖筛选，获得 了一头孕期高血糖的个体，这头猪生产了11 头后代( 存活10 头) ，我们以这10 头小型猪为基础，以高糖高脂饲料 诱导过程的表现性状作为选育条件，经过2 世代的选育，小型猪的糖尿病易感性从诱导7 个月发病，进展为6 个月 发病。因此，推测有希望获得一个糖尿病易感的小型猪新品系。

关键词: 小型猪, 2 型糖尿病, 巴马小型猪, 遗传选育