Abstract: Abstract:Objective To analyze the effects of different types of endurance training on oxidative stress of myocardial tissue in Sprague-Dawley rats，and thereby to provide rational movement scheme to improve the myocardial antioxidant capacity． Method A total of 48 male SD rats (6 weeks) were enrolled in the study． The study consisted of control group (n = 12)，low intensity exercise group (n = 12)，moderate intensity exercise group (n = 12) and highly intensity exercise group ( n = 12)． The endurance exercise training groups exercised for 6 weeks and the control group maintained their daily eating habits． superoxide dismutase (SOD) activity，glutathione peroxidase (GSH － Px) activity，malondialdehyde (MDA) content were measured after the 6 weeks experiment． Result After 6 weeks endurance exercise training intervention，compared with control group，the SOD activity were higher in moderate intensity exercise group (P ＜ 0． 01)，and significantly higher in highly intensity exercise group (P ＜ 0． 01);the GSH － Px activity were higher in low and moderate intensity exercise group (P ＜ 0． 05 or P ＜ 0． 01)，and significantly higher in highly intensity exercise group (P ＜ 0． 01)． Moreover，the levels of MDA significantly enhanced in highly intensity exercise group (P ＜ 0． 01)． Conclusion The low and moderate intensity exercise group were effective in improve the myocardial antioxidant capacity of rats，particularly in moderate intensity exercise group．

Key words: endurance exercise training, oxidative stress, myocardial tissue, SD rats

摘要： 摘要: 目的 观察不同强度耐力训练对雄性大鼠的心肌氧化损伤及凋亡的影响，探讨增强心肌抗氧化能力的适宜 训练方式。方法 选用 6 周龄健康雄性大鼠 48 只，建立大鼠耐力跑台模型。将选取的大鼠随机分为 4 组:安静对 照组(C 组，12 只);低强度组(L 组，12 只);中等强度组(M 组，12 只);高强度组(H 组，12 只)。4 组大鼠进行为期 6 周的跑台实验后，用生化方法分别检测各组大鼠的氧化应激相关指标，内容包括:心肌组织的超氧化物歧化酶 (SOD)活力、谷胱甘肽过氧化物酶(GSH-Px)活力以及丙二醛(MDA)的含量。结果 4 组大鼠经不同强度耐力运 动训练 6 周后，结果发现，与安静对照组相比，心肌组织的 SOD 活力在中强度组显著上升，而在高强度组显著下降 (P ＜ 0． 01);GSH-Px 活力在低强度组和中等强度组显著上升，而在高强度组显著下降(P ＜ 0． 05 或 P ＜ 0． 01);与安 静对照组相比，高强度组的心肌组织 MDA 水平显著增高(P ＜ 0． 01)。结论 低中强度的耐力训练能有效提高心肌 的抗氧化能力，尤其是中等强度的耐力训练。

关键词: 耐力运动, 氧化应激, 心肌组织, SD 大鼠