Abstract: Abstract:In order to measure survival，body weight and food intake of Wistar rats feeding for two years，tumor occurrence and survival of Wistar rats were observed for two years，and food intake and body weight were investigated weekly． The results showed mortality and survival time of male rats were higher than female rats， spontaneous tumor incidence of female rats were slightly higher than male rats，and multi-organ tumors were found in one animal． Compared with female rats，food intake and water intake of male rats had no apparent change trends． Body weight grew obviously in earlier and obtained peak later，and then declined slightly． Daily food consumption and body weight percentage declined earlier in the test，and slightly rebounded after the minimum value was reached． Normal reference range of Wistar rats feeding for two years was set up in order to evaluate

Key words: Wistar rats, survival, carcinogenicity, body weight, food intake

摘要： 摘要:目的Wistar 大鼠二年喂养对其生存、体质量及进食量进行观察与分析。方法对Wistar 大鼠连续2 年观察 其肿瘤发生及生存情况。每周测定大鼠的体质量和进食量。结果雄性大鼠死亡率、死亡动物平均活存时间具有 高于雌性大鼠的趋势，雌性大鼠的自发性肿瘤发生率较雄性大鼠略高，并且存在同一只大鼠多器官发生肿瘤的现 象。实验期间雌雄大鼠进食量与进水量无明显变化，体质量在实验早期持续增长，在实验中晚期达到峰值，此后略 有下降。日摄食量与体质量百分比在实验早期呈下降趋势，在实验中晚期达到极小值后略有回升。结论建立了 Wistar 大鼠实验室相关的正常值参考范围，为建立和开展新药对啮齿类动物致癌性试验的评价提供依据。

关键词: Wistar 大鼠, 生存, 致癌性, 体质量, 进食量