Abstract: Abstract:Objective To investigate the effects of Hulan hypoglycemic sustained-release tablets( TGE) on glucose and lipid metabolism and islet function in diabetic animal model． Method The animal models of diabetes mellitus was established by intraperitoneal injection of streptoztocin ( STZ) 40 mg / kg． The rats were divided randomly into four groups:normal control group，diabetic group，western medicine group( repaglinide) and Hulan hypoglycemic sustained-release tablets group． After different administration for 4 weeks，the rats were killed and blood sample was collected for fasting blood glucose ( FBG ) ，Triglyceride ( TG )，total cholesterol ( CHO )，high-density lipoprotein cholesterol ( HDL-C) and low density lipoprotein cholesterol ( LDL-C) and fasting insulins ( FINS ) ． Ｒesult Compared with other，the pancreas was fixed for intervention groups，TGE group had lower blood glucose(P ＜ 0. 05) ． Compared with normal control group，other group shown lower FINS(P ＜ 0. 05) ． Compared with diabetic group，western medicine group no difference for FINS(P ＞ 0. 05)，but the difference of FINS was observed between TGE group and diabetic control group ( P ＜ 0. 05 ) ． Conclusion Hulan hypoglycemic sustained-release tablets have a modulatory role in glucose and lipid metabolism and function of pancreatic islet in diabetic animal model．

Key words: Hulan hypoglycemic sustained-release tablets, diabetic mellitus, rats, glucose and lipid metabolism

摘要： 摘要:目的观察胡蓝降糖缓释片( TGE)对糖尿病大鼠模型糖脂代谢状态和胰岛功能的影响。方法对SPF 级雄 性Wistar 大鼠予以链脲佐菌素( STZ)40 mg / kg 腹腔注射，建立糖尿病动物模型。设立正常对照组、糖尿病组、二甲 双胍对照组及胡蓝降糖缓释片干预组( TGE 组)。二甲双胍对照组及TGE 组分别予以盐酸二甲双胍和胡蓝降糖缓 释片灌胃;4 周后杀鼠留取血样检测空腹血糖( FBG)、甘油三酯( TG)、胆固醇( CHO)、高密度脂蛋白胆固醇(HDLC) 、低密度脂蛋白胆固醇( LDL-C)、糖化血红蛋白( HbA1 c)。采用放射免疫法( ＲIA)检测血清空腹胰岛素( FINS) 水平。结果TGE 显著降低糖尿病大鼠血糖，差异显著(P ＜ 0. 05) ;TGE 提高糖尿病大鼠FINS 水平，差异显著( P ＜ 0. 05)。结论胡蓝降糖缓释片对糖尿病大鼠模型糖脂代谢紊乱及胰岛功能有一定的调节作用。

关键词: 胡蓝降糖缓释片, 糖尿病, 大鼠, 糖脂代谢