Abstract: Abstract:Objective To investigate the effects of rutin on ＲOCK I protein in STZ-induced DCM． Method DCM model was induced by STZ． 24 male Waster rats were randomly divided into control group ( n = 6)，STZ group ( n = 6)，rutin + STZ group ( n = 6)，Positive drug + STZ group ( n = 6 ) ． The rats of the treatment groups were given rutin，DCM group and normal group were given 0. 9% sodium chloride． The index of rats after intervention of rutin morphology，collagen content and ＲOCK I protein were observed． Ｒesult After injection of STZ，collagen and ＲOCK I protein expression increased compared with normal control group( P ＜ 0. 05) ． After rutin treatment， its value reduced as compared with the model group． And HE staining showed that the degree of cardiac injury reduced after rutin treatmenr． Conclusion Ｒutin may regulate the expression of ＲOCK I and reduce myocardial injury． Specific mechanism needs further study．

Key words: STZ, ＲOCK I, rutin

摘要： 摘要:目的探讨罗布麻提取物芦丁对链脲佐菌素( STZ)诱发的大鼠糖尿病心肌病( diabetic cardiomyopathy，DCM) ＲOCK I 蛋白的影响。方法用STZ 诱发糖尿病心肌病模型，24 只雄性Wistar 大鼠随机分为正常对照组、DCM 组 ( STZ)、阳性药组( STZ + 卡托普利)及芦丁治疗组( STZ + 罗布麻提取物芦丁)，每组6 只。治疗组大鼠给予芦丁灌 胃，DCM 组和正常对照组大鼠给予0. 9% 氯化钠注射液灌胃。治疗后行大鼠形态学观测、测定胶原蛋白及ＲOCK I 蛋白表达。结果注射STZ 后，大鼠胶原蛋白及ＲOCK I 蛋白的表达较正常对照组增加( P ＜ 0. 05)，罗布麻提取物 芦丁灌胃后，其表达相对于模型组降低;HE 染色结果显示，给予芦丁后心肌损伤程度减轻。结论罗布麻提取物 芦丁可减轻心肌损伤，其机制可能与降低ＲOCKI 蛋白表达有关。

关键词: 链脲佐菌素, ＲOCK I, 芦丁