Abstract: Abstract: Some apparatuses such as heart，liver，spleen，lung，kidney，large intestine and small intestine were drawn from laboratory rodents sampling from 16 units of Beijing in May 2012，and were prepared into serial paraffin sections stained with HE and the frozen sections stained with Oil Red O and PAS for microscopic analysis． The results showed that most of the laboratory rodents remained in good condition，and liver fatty degeneration，slight lung lesion，heart granular degeneration and protein cast of kidney were revealed in a few laboratory rodents． We have the impression that these lesions may be associated with feedstuff，feeding environment and transportation stress，and may be improved by strengthening the feeding management．

Key words: laboratory rodents, pathological diagnosis, organ lesions

摘要： 病理学观察，通过石蜡切片HE 染色、冰冻切片油红O 染色、PAS 染色等方法对啮齿类实验动物的健康状况进行鉴 定。结果显示，绝大多数啮齿类实验动物为健康状态，部分非健康动物主要有肝脏脂肪变性、轻度肺脏病变、心脏 颗粒变性和肾脏蛋白管型。这可能与饲养环境、饲料状况以及采样运输的应激有关，通过加强饲养管理可以使这 种情况改善。

关键词: 啮齿类实验动物, 病理学诊断, 脏器病变