Abstract: 0bjective To study the effect of the extraction temperature on the pharmacodynamic of Radix Bupleuri in decoction．Methods Through The experiments adopted the Lipopolysaccharide rat model of fever and the mouse pinna swelling induced by xylene，Then discussed the pharmacodynamic effect of Radix Bupleuri in decoction respectively at 60。C and I 00。C．Results First，Radix Bupleuriin decoction both have a certain antipyretic role at at 60。C and 100。C，Build the 4 h and 5 h temperature drop compared with model control group has significant difference(P<0．05)，The effects are almost same as aspirin，and antipyretic role lasted stability，butthe antipyretic actions of Radix Bupleurisolution is poorer got at 1 00℃．Second．Radix Bupleuriin decoction made by two producing methods both have better antiinflammatory action．mouse pinna swelling group were extremely significant difference compared with the control group(P<0．01)，the antiinflammatory action of Radix Bupleuriin decoction B extracted at 60℃are better than decoction A extracted at 100。C．but they are not significant． Conlusion The antipyretic role of Radix Bupleuri in decoction are better at 60。C，it is not significant effect of antiinflammatory action on extraction temperature．

Key words: extraction temperature, Radix Bupleuri, antipyretic role, antiinflammatory action

摘要： 目的研究了提取温度对柴胡水提取液药效作用的影响。方法采用脂多糖致大鼠发热模型和二甲苯致小 鼠耳廓肿胀模型，分别研究了60。C和100。(2时提取制备的柴胡水提取液的药效作用。结果1)60。C和100％提取 时所得的柴胡水提取液均有一定的解热作用，其中60℃条件制备的柴胡水提取液(B液)，在造模后4 h和5 h体温 降幅与模型对照组相比差异显著(P<0．05)，其作用效果与阿司匹林相当，且解热作用稳定持久；而100。C时所得 的柴胡药液(A液)解热作用较差。2)两种制备方法所得的柴胡水提取液均有较好的抗炎作用，耳廓肿胀度与空白 对照组相比差异均极显著(P<0．01)，60℃时柴胡提取液B的抗炎作用好于100％时柴胡提取液A的抗炎作用，但 差异不显著。结论60。C时柴胡提取液解热效果更佳，提取温度对柴胡的抗炎作用无明显影响。

关键词: 提取温度, 柴胡, 解热作用, 抗炎作用