Abstract: Objectives: To investigate the effects of single pancreatic juice reflux on esophageal mucosa，and to establish rat models of reflux esophagitis．Methods:We produced esophagitis in two experimental groups of Sprague-Dawley rats: Group A, gastrectomy and end-to-side esophagojejunostomy and bile-duct-jejunostomy; Group B, control group. The esophageal samples were taken at different time after operation and studied．Results:Most of the rats in reflux group displayed evidence of reflux esophagitis，which was more severe in lower part of esophagus than in upper part，and more severe with postoperation time．The main histologic changes were inflammation, erosion，ulcer and epithelial cell hyperplasia．Esophageal mucosa injury was most severe in A group，then in B group．Conclustions:These results suggest that models of single pancreatic juice reflux esophagitis be successfully made．The pancreatic juice can injury esophageal mucosa seriously．It may play an important role in the pathogenesis of GERD and its complications．

Key words: font-size: 10.5pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 仿宋_GB2312" lang="EN-US">Itopride Hydrochloride, acid reflux esophagitis, animal model.

摘要： 目的了解单纯胰液反流对食管粘膜的损伤作用。方法运用全胃切除+食管十二指肠端侧吻合术+胆管 空肠吻合术制作单纯胰液食管反流，并于不同时间分批取得食管标本进行组织形态学研究。结果实验组均出现 程度不等的反流性食管炎，病变以食管下段为重，随病程延长加重，组织学表现为炎症、糜烂溃疡、上皮高度增生及 出现化生柱状上皮。结论胰液能造成明显食管粘膜损伤，可能在胃食管反流病(GERD)及并发症的发生中具有 重要意义。

关键词: 胰液, 食管炎, 反流A