Abstract: objective To evaluate the safety of external applied Chinese traditional medicine“Ai zheng zhen tong san”. Method To make use of skin irritation test of rabbit, skin allergy test of guinea pig, skin acute toxicity test of rabbit, skin long term toxicity test of rabbit to carry out the evaluation. Results When“Ai zheng zhen tong san” was external applied under equivalent dose and concentration of clinical use, it doesn't induce allergic reaction in guinea pigs, but has a slightly irritation to rabbit skin. While external applied under high doses, it appeared slightly irritating to rabbit skin in cute toxicity test, and induced skin incrassation and connective tissue hyperplasia in corium layer in long term toxicity test, no systemic toxicity were observed. Conclusion “Ai zheng zhen tong san” is considered safety when it be used as suggesting clinic dose and concentration.

Key words: Chinese traditional medicine, Analgesic

摘要： 为了进一步研究中药“癌症镇痛散”的安全性 ,进行了家兔皮肤刺激试验、豚鼠皮肤过敏试验、家兔皮肤急性毒性试验和皮肤长期毒性试验。结果显示 ,“癌症镇痛散”外用对家兔皮肤有轻度刺激性 ;大剂量 (2g kg ,6g kg)单次应用也只表现皮肤局部轻度刺激反应 ;大剂量 (3g kg ,8g kg)连续应用 2个月 ,表现出用药局部皮肤增厚、真皮浅层结缔组织轻度增生 ,未见全身毒性反应 ;不能引起豚鼠过敏反应。提示“癌症镇痛散”在临床试用剂量下是基本安全的

关键词: 中药, 镇痛药, 毒理学