Abstract: objective To investigate the effect of she xiang kai qiao granule on mental disorder. Method ICR mice weighted 20-24g were divided into:the low ,the middle ,the high dosage(1 00,2 00,4 00g crude/kg),the model, the positive drug control and the negative control group. The drugs were administered (i.g) daily for 15 days, the effect of she xiang kai qiao granule was examined by the Y water maze test, the step down test and swimming in cold for mice. Results 1.In step down test, she xiang kai qiao granule was decreased the errors of respouse and prolonged the latent period, which showed a significant difference ( P<0 05,P<0 01,P <0 05)in every dosage group compared with model group. 2.She xiang kai qiao granule have a protective effect for the mice disorientation. From the 4th day, the number of errancy showed a significant difference( P <0 05) in high and middle dosoge group compared with model group. 3.She xiang kai qiao granule can improved on strength and endurance in some degree ( P <0 05).Conclusion She xiang kai qiao granule can improved mental disorder of mice significantly.

Key words: She xiang kai qiao granule, Scopolamice, Phenobarbital, Memory

摘要： 目的　观察麝香开窍颗粒对智力低下小鼠的疗效。方法　选用ICR小鼠 ,分为麝香开窍颗粒高、中、低剂量(4 0 0、2 0 0和 1 0 0g生药 kg)组 ,模型组 ,阳性对照组和空白对照组。连续灌胃给药 15d ,进行小鼠跳台、Y型水迷路及冰水游泳实验。结果　 (1)在跳台实验中麝香开窍颗粒能使小鼠获得性记忆障碍模型的触电潜伏期延长 ,遭受电击的错误次数减少 ,与模型组比较 ,有显著和极显著差异 (P <0 0 5和P <0 0 1)。 (2 )麝香开窍颗粒对戊巴比妥所致方向辨别障碍性模型动物有保护作用 ,从训练的第 4d开始 ,高、中剂量组方向辨别的错误次数与模型组比较 ,有显著性差异 (P <0 0 5 )。 (3)麝香开窍颗粒能在一定程度上提高机体的应激能力和耐受力 (P <0 0 5 )。结论　麝香开窍颗粒能明显地改善小鼠智力障碍

关键词: 麝香开窍颗粒, 东莨菪碱, 戊巴比妥, 记忆