Abstract: To observe the effect and dose effect relationship of recombinant human epidermal growth factor (rh\|EGF) on burn wound healing in rabbits, 15 rabbits were randomly divided into 5 groups, which were 3 different concentrations of rh\|EGF, rh\|EGF matrix and blank control respectively. 6 wounds of two degree burn wound were prepared on the back of each rabbit. The healing effect was assessed by measuring burn area and histology. All the burn areas were reducing with time duration, high dose rh\|EGF had the best effect, the wound re\|epidermidalization and growth granulation actively. It suggested that rh\|EGF could accelerate wound healing and exhibit a certain dose\|effect relationship, the high dose rh\|EGF (50μg/g)has the better effect.

Key words: Epidermal growth factor, Burn, Wound heal4

摘要： 观察重组人表皮生长因子 (rh EGF)对兔深II度烫伤创面愈合的作用及其量效关系。将 1 5只兔随机分成 5组 ,即 3个剂量rh EGF组、rh EGF基质组及空白对照组。每只兔的背部制成 6个深II度烫伤创面 ,治疗后以烫伤创面面积的变化 ,组织学改变评价愈合效果。结果各组烫伤创面面积随伤后时间延长而逐渐缩小 ,其中以rh EGF高剂量组治疗的创面缩小最为明显。组织学检查可见经rh EGF高剂量组治疗的创面肉芽组织生长活跃 ,创面的再上皮化迅速。rh EGF可以加快烫伤创面组织愈合速度并显示出一定的量效关系 ,即高剂量组 (50 μg/g)效果最佳

关键词: 表皮生长因子, 烫伤, 创面愈合