Abstract: ? The high serum levels of thyroid hormones in rats were induced by oral administration of thyroid tablets (average dose for each rat:4 mg/d ×6d). The activities of β\|acceptor in myocardium and plasma catecholamine were measured. The results showed that the activity of β\|acceptor was 69±13 fmol/mgpro, at the end of the administration and was lower than that in control group(94±22 fmol/mgpro),the activity of plasma catecholamine(NE:530±73 pg/ml, E:132±62pg/ml) was higher than those in control one(NE:318±117 pg/ml,E:98±36 pg/ml). These results indicate that the changes of β\|acceptor and catecholamine play an important role in the development of themyocardium damnification under high serum levels of thyroid hormones.

Key words: Thyroid hormones\ Myocardium\ β\|Acceptor\ Catecholamine\ Rat

摘要： 为研究高甲状腺激素状态下心肌β受体、血浆儿茶酚胺（ＣＡ） 的变化及相互关系，给大鼠口服甲状腺片，平均每只４ ｍｇ／ｄ ，连续６０ ｄ ，检测心室肌β受体密度最大结合量（Ｂｍａｘ） 和血浆儿茶酚胺含量。结果显示，实验组大鼠心肌Ｂｍａｘ（６９ ±１３ ｆｍｏｌ／ｍｇｐｒｏ） 显著低于对照组（９４ ±２２ ｆｍｏｌ／ｍｇｐｒｏ） ；实验组大鼠血浆ＣＡ（ＮＥ：５３０ ±７３ ｐｇ／ｍＬ， Ｅ：１３２ ±６２ ｐｇ／ｍＬ） 显著高于对照组（ＮＥ：３１８ ±１１７ ｐｇ／ｍ Ｌ，Ｅ：９８ ±３６ ｐｇ／ｍＬ） 。提示高甲状腺激素水平作用下，心肌β受体Ｂｍａｘ 下降和血浆ＣＡ 升高是造成心肌损伤的重要原因

关键词: 甲状腺激素, 心肌, β受体, 儿茶酚胺