Abstract: Memory impairment is the primary symptom of numerous neurological diseases and represents a hot and challenging issue in current neuroscience research. The development of animal models of memory impairment serves as the foundation for research on nervous system disorders. Multiple chemicals are utilized in the creation of memory impairment models due to their ability to interfere with or disrupt the function of biological macromolecules. This article comprehensively reviews the specific types and mechanisms of memory impairment induced by various chemicals, offering a theoretical basis for the study of memory impairment models and novel insights into exploring approaches to ameliorate memory impairment.

Key words: memory impairment, animal models, Alzheimer’s disease, Parkinson’s disease

摘要： 记忆障碍是多种神经疾病的主要症状,是当今神经科学研究的热点和难点问题。记忆障碍动物模型的建立 是神经系统疾病的研究基础,多种化学物质可干扰或破坏生物大分子功能,常被用于构建记忆障碍模型。本文综 述了多种化学物质所致记忆障碍具体类型及机制,为记忆障碍模型的研究提供理论基础,为改善记忆障碍提供 思路。

关键词: 记忆障碍, 动物模型, 阿尔茨海默病, 帕金森病