关键词: 柴胡疏肝散精简方, 抑郁疼痛共病, 行为学

Abstract: Objective　To observe the effect of Simplified Chaihu Shugan Powder(SCSP) on behaviors of depression-pain comorbidities rats.Methods　Thirty-two SPF male SD rats were randomly divided into control group, model group, fluoxetine group, SCSP group, with each group consisting of 8 rats. Each drug group was made by intraperitoneal injection of reserpine, fluoxetine hydrochloride was used as the positive control drug, and each drug group was given the corresponding drug by intragastric administration for 14 days.At the end of the experiment, we measured the body weight, we use forced swimming test, sucrose preference test,open field test to evaluate the depressive status. We use thermal withdrawal latency(TWL)and paw withdrawal thresholds(PWT)to evaluate the pain sensation.Results　Compared with the control group, the body weight,body weight gain,sugar water preference index,total distance and numbers of crossing grids of open field experiment in model group decreased significantly (P<0.01); immobile time of forced swimming test in model group increased significantly (P<0.01);the foot retraction time of TWL, foot retraction threshold of PWT decreased significantly (P<0.01) in model group. Compared with the model group, the body weight,body weight gain,total distance and numbers of crossing grids of open field experiment in SCSP group increased significantly (P<0.01); sugar water preference index increased in SCSP group (P<0.05);immobile time of forced swimming test in SCSP group decreased significantly (P<0.01);the foot retraction time of TWL, foot retraction threshold of PWT increased significantly (P<0.01) in SCSP group.Conclusion　SCSP can effectively increase the body weight gain of depression-pain comorbidities rats, partially combat the behavioral changes caused by reserpine, improve despair, loss of pleasure, decreased exercise ability and pain of depression-pain comorbiditis rats, and achieve the effect of relieving depression and pain.

Key words: simplified Chaihu-Shugan powder, depression-pain comorbidities, behaviors