关键词: 电针, APP /PS1, Morris 水迷宫, 学习记忆

Abstract: Abstract:Objective To explore the effect of electro-acupuncture on learning and memory behavior of five months APP / PS1 transgenic AD mice． Method 16 APP /PS1 transgenic positive male mice were randomly divided into the model group and the electro-acupuncture group，8 in each group． At the same time，there were 8 APP /PS1 transgenic negative male mice as the normal control group． The“baihui”and“yongquan”of electro-acupuncture group were acupunctured using dilatational wave for 15 min ，every other day at a time． By the same method ，the mice of control and model group were bounded by binder for 15 min． The all three groups were treatmented for five weeks． Finally the ability of learning and memory of all mice was tested by Morris water maze． Ｒesult Escape latency between three groups was statistically significant( P ＜ 0. 05 )，escape latency between the model group and the electro-acupuncture group was statistically significant ( P ＜ 0. 05 ) ． Conclusion Electro-acupuncture can improve learning and memory ability of APP /PS1 transgenic AD mice．

Key words: electro-acupuneture, APP /PS1, Morris water maze test, learning and memory behavior