关键词: 恩诺沙星, 豚鼠, 血液生理指标, 血液生化指标

Abstract: Objective To study the effects of different routes of enrofloxacin administration on bodyweight and blood physiological and biochemical indexes of guinea pigs, this study was performed.Method The effects of different routes of enrofloxacin administration on body weight,blood physiologicaland biochemical indexes of guinea pigs were determined respectively. Statistical method were used fordata analysis. Result High dose of enrofloxacin administered by drinking water significantly affected thewater consumption of guinea pigs. Both high dose of enrofloxacin and low dose of enrofloxacinsignificantly affected the weight gain of guinea pigs. Compared to the control group, several significantlydifferent blood physiological indexes were determined in the administration treatment groups includingWBC, MON, GRAN, MCHC, RDW-CV, PDW. In terms of blood biochemical indexes, five parameters(Ca, ALT, ALP, γ-GT, and TG) were also affected after administration, compared to the control第 3 期 董 浩等:不同途径给药恩诺沙星对豚鼠体质量和血液生理生化指标的影响group. Conclusion The determination of the effects of different routes of enrofloxacin administration onseveral biological indexes of guinea pigs would provide basic data for scientific medication in guinea pigs.

Key words: enrofloxacin, guinea pigs, blood physiological indexes, blood biochemical indexes