三种饮用水对 NIH 小鼠血液指标的影响

doi:10.3969/j.issn.1006-6179.2024.03.008

实验动物科学 ›› 2024, Vol. 41 ›› Issue (3): 46-50.DOI: 10.3969/j.issn.1006-6179.2024.03.008

三种饮用水对 NIH 小鼠血液指标的影响

( 1. 中国食品药品检定研究院实验动物资源研究所,北京 102629)

收稿日期:2023-05-05 出版日期:2024-06-28 发布日期:2024-06-03
通讯作者: 刘佐民( 1963—) ,男,副研究员,研究方向为实验动物管理,E-mail:liuzuomin@ nifdc. org. cn。
作者简介:王学文( 1979—) ,女,兽医博士,研究方向为实验动物学,E-mail:wangxuewen320@ 163. com。

Effects of Three Kinds of Drinking Water on Blood Indexes in NIH Mice

( 1. Institutes for Laboratory Animal Resourses, National Institutes for Food and Drug Control, Beijing 102629,China)

Received:2023-05-05 Online:2024-06-28 Published:2024-06-03

摘要/Abstract

摘要： 目的探讨三种饮用水对 NIH 小鼠血液指标的影响。方法将 54 只 NIH 小鼠随机分为 3 组,分别饮用高压灭菌水、高压酸化水和无菌水袋水(膜过滤水) ,在实验 30、60 和 90 d 分别取血进行血常规和血生化检测,并取肝组织进行组织病理学检查,探讨三种饮用水对小鼠健康状态的影响。结果 60 d 水袋水组白蛋白( ALB) 显著高于高压灭菌水组(P<0. 05) ,酸化水组总蛋白( TP)极显著高于高压灭菌水组( P< 0. 01) ,其他生化和血常规指标组间无统计学意义(P>0. 05) ,肝组织病理学结果显示各组小鼠肝组织未发现病变,为正常肝组织。结论三种饮用水对NIH 小鼠健康状态无明显影响

关键词: 三种饮用水, NIH 小鼠, 血液指标

Abstract: Objective To explore the effects of three kinds of drinking water on blood indexes in NIHmice. Method 54 NIH mice were randomly divided into three groups, drinking autoclaved water,autoclaved acidified water and sterile water bag water ( membrane filtered water) , respectively. On the30th, 60th, and 90th days of the experiment, blood was taken for blood routine and biochemical tests,and liver tissue was taken for histopathological examination to explore the effects of three kinds of drinkingwater on the health status of mice. Result The albumin ( ALB) in the 60 day water bag group wassignificantly higher than that in the autoclaved water group ( P < 0. 05) , the total protein ( TP ) in theautoclaved acidified water group was significantly higher than that in the autoclaved water group ( P <0. 01) , and there was no significant difference between the other groups ( P > 0. 05 ) . The liverhistopathological result showed that no pathological changes were found in the liver tissues of mice in eachgroup, and they were normal liver tissues. Conclusion Three kinds of drinking water have no significantimpact on the health status of NIH mice.

Key words: three kinds of drinking water, NIH mice, blood indicators

中图分类号:

Q95-3

王学文, 吴征宏, 彭卫娟, 邱丽媛, 董浩, 左琴, 刘佐民. 三种饮用水对 NIH 小鼠血液指标的影响[J]. 实验动物科学, 2024, 41(3): 46-50.

WANG Xuewen, WU Zhenghong, PENG Weijuan, QIU Liyuan, DONG Hao, ZUO Qin, LIU Zuomin. Effects of Three Kinds of Drinking Water on Blood Indexes in NIH Mice[J]. Laboratory Animal Science, 2024, 41(3): 46-50.

[1]	高安崇, 陈健, 王大力, 梁爽, 袁宝. 不同饲养方式对英国短毛猫生长性能及血液指标的影响[J]. 实验动物科学, 2023, 40(6): 32-37.
[2]	郭羽, 魏杰, 王锡岩, 张梦媛, 胡涛, 闵凡贵, 王洪, 岳秉飞. Tiantanbio: NIH 小鼠血液生理生化和脏器指标的测定分析[J]. 实验动物科学, 2016, 33(06): 45-49.
[3]	张晓玉, 张修彦, 陈沃勋, 梁宁, 詹纯列. SPF 级FMMU 白化豚鼠基础生理指标的测定与比较[J]. 实验动物科学, 2015, 32(04): 31-35.
[4]	卢静,董洁,王钜,杨果杰. 长爪沙鼠的血液及血清生化测定值[J]. 实验动物科学, 1999, 16(02): 0-0.

三种饮用水对 NIH 小鼠血液指标的影响

Effects of Three Kinds of Drinking Water on Blood Indexes in NIH Mice

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics