实验动物科学 ›› 2022, Vol. 39 ›› Issue (1): 65-.

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生殖毒性特征指标的统计分析 

  

  1. (山东省药学科学院新药评价中心,济南 250101)
  • 出版日期:2022-02-28 发布日期:2022-03-21

Statistical Analysis of Reproductive Toxicity Characteristic Indicators 

  1. ( Shandong Academy of Pharmacetical Sciences, New Drug Evaluation Center, Jinan 250101,China)
  • Online:2022-02-28 Published:2022-03-21

摘要: 摘要:生殖毒性实验产生的数据量大及种类多,因此数据的处理显得尤为重要本文归纳汇总生殖毒性实验中产生的各类指标,并详述各类数据适于选择的统计方法,以及各种方法的优缺点,尤其是对具有窝效应特点的胎仔数据的分析进行了详细阐述生殖毒性实验产生的母体数据可选择现有的统计方法进行分析,但这些常规统计分析方法未考虑到胎仔数据中窝效应和窝大小的不均一性,本文提出的随机效应 logistic 回归模型广义估计方程多水平模型等或者百分率统计和频数统计相结合的方法均能考虑到窝效应,对胎仔数据做出正确的统计分析本文提出的各种模型和统计方法为生殖毒性实验产生的常规数据和窝效应数据提供了简便科学的统计分析方法

关键词: 关键词:生殖毒性, 窝效应, 统计

Abstract: Abstract:The amount of data produced by the reproductive toxicity study is large, and there are many types of data, so it is particularly important to process the data. This paper described the various types of indicators and the indicators were divided into 4 categories. The study also discussed the analysis method of the reproductive toxicity study data according to the characteristics and distribution of data and the advantages and disadvantages of the analysis method, especially the analysis of the litter data with litter effects. The maternal data generated by the reproductive toxicity study can be analyzed by existing statistical method, but these conventional statistical analysis method did not take the litter effect and the litter size into account. So this study provided some models which were suitable for the data of litter effect such as random effects logistic regression models, generalized estimating equations, multi-level models. The analysis method which the paper provided were simple and scientific for the reproductive toxicity study data.

Key words: Key words:reproductive toxicity, litter effect, statistics