实验动物科学 ›› 2021, Vol. 38 ›› Issue (4): 6-.

• 研究报告 • 上一篇    下一篇

病理学在人类疾病实验动物模型评价中的作用和意义

  

  1. (中国农业大学,北京 100193)
  • 出版日期:2021-08-28 发布日期:2021-10-25

The Roles and Significance of Pathology in the Evaluation of Animal Models of Human Diseases

  1. ( China Agricultural University, Beijing 100193, China)
  • Online:2021-08-28 Published:2021-10-25

摘要:

摘要:疾病始终与人类共存,威胁着人类健康,给人类医学的发展和进步不断带来新的挑战。 实验动物模型是揭示人类疾病致病机制,研发防治技术和产品的“必备工具”与“重要载体” 。 实验动物模型创制的成功与否,可直接影响研究结果的科学性、准确性和可靠性。 因此,病理学作为疾病诊断的“金标准” ,不仅为实验动物模型评价提供最直接的“证据” ,进而协助动物造模设计、优化造模条件、优选造模动物等,而且有助于评价动物模型的特征性病变,直接反映病变发生的位置、类型、阶段、程度等,同时发现造模可能伴发的病变,排除非特征性病变及背景病变干扰,有利于分析造模方法与疾病的相关性,筛选出最适宜的动物模型。 由此可见,病理学在实验动物模型评价中发挥着不可或缺的作用。

Abstract:

Abstract:Diseases have always coexisted with humans, threatened human health, and brought new challenges to the development and progress of human medicine. Animal models are “ essential tools” and “ important carriers” for revealing the pathogenic mechanism of human diseases and developing prevention and treatment technologies and products. The success of the development of animal models can directly affect the scientificity, accuracy and reliability in medical research result. Therefore, objective assessment for the animal models is particularly  important. As the “ gold standard” for disease diagnosis, pathology not only provides the most direct evidence for the evaluation of experimental animal modeling, and then assists in animal modeling design, optimization of modeling conditions, and optimization of modeling animals, etc. , but also helps to evaluate the characteristic lesions of animal models and directly reflect location, type, stage, degree, etc. , and at the same time, discover the lesions that may be associated with modeling, and exclude non-characteristic or background lesions. It is helpful to analyze the correlation between the modeling method and the disease, and screen out the most suitable animal model. Therefore, pathology plays an indispensable role in the assessment of animal models.

Key words: ">animal models丨 pathology丨assessment