Abstract:Genetic quality monitoring is one of the most important composition of laboratory animal quality control.It is essential method to find the genetic variation in laboratory animal and to confirm standardized animal quality. With the development of science and technology, especially with biological science progress, the technique of laboratory animal quality monitoring boosts from morphological genetic markers to DNA molecular level, and become more accurate, convenient and speedy. We sort out the history about methods in laboratory animal quality control, compare and analyze the advantages and limits of these methods, discuss the bright prospect of their application as well.