关键词: 颈总动脉球囊拉伤, 大鼠, 动物模型

Abstract: Objective To optimize the establishment of rat carotid artery balloon-injured model and to improve success rate in it. Method Twenty -five Sprague-Dawley ( SD) rats were randomly divided into three groups. The rats' left carotid artery in group A were deendothelialized by passing an inflatable balloon catheter ( size 2 mm, Cordis) . The rats' left carotid artery in group B were deendothelialized by passing an inflatable balloon catheter (size 1. 5 mm, Cordis) . The rats' left carotid artery in group C were made an arteriotomy without passing balloon catheter. The effect of balloon injury was assessed via Ivans ’ blue staining. Result The success rate in establishment of rat carotid artery balloon-injured model of group A is 45. 5% (5/11) . The success rate of group B is 90. 9% ( 10/11) ( P = 0. 032) . The difference of injured carotid artery intima area between group A and B is not significant ( P = 0. 426 ) . Conclusion The application of 1. 5 mm inflatable balloon catheter could successfully denude the intima of carotid artery in rats and could significantly improve the successful establish rate of rat carotid artery balloon-injured model.

Key words: Balloon injury in carotid artery , rats , animal model