关键词: 肺炎支原体, 肺炎支原体肺炎, 纤维素沉积, 动物模型

Abstract: Objective Mycoplasma pneumoniae pneumonia ( MPP ) is an interstitial pneumonia caused by Mycoplasma pneumoniae ( MP ) with fibrous connective tissue hyperplasia in the pulmonary interstitial as the main pathological change , in clinically susceptible patients with chronic lung inflammation. For this reason , the study used a method of smoking and Mycoplasma pneumoniae infection to establish an experimental animal model of Mycoplasma pneumoniae interstitial pneumonia. Method Realtime PCR , HE and Masson staining were used to observe the concentration of Mycoplasma pneumoniae and the deposition of cellulose in lung tissue after infection in mice. Result In the smoked and infected group, the infection rate of Mycoplasma pneumoniae was 93%, the alveolar cavity collapsed , a flaky dense structure in the lung tissue , and thered blood cells filled with alarge amount of cellulose. Conclusion The lung tissue lesions of the smoked and infected mice are severe , showing a state of cellulose deposition .The model of chronic lung inflammation combined with Mycoplasma pneumoniae interstitial pneumonia was successfully established.

Key words: Mycoplasma pneumoniae, Mycoplasma pneumoniae pneumonia, Cellulose deposition, Animal model