关键词: 妊娠期高血压, Ⅰ型脱碘酶, 实时荧光定量PCR, 甲状腺激素

Abstract: To investigate the effect of HDCP on DIO- I and thyroid hormone. Method Twenty pregnant rats were divided into control group ( n = 10 ) and model group ( n = 10 ) . On the 13 th day of gestation , rats in model group were received L-NAPE by subcutaneous injection until 21th day of gestation , HDCP model was reproduced. Control group received saline by the same ways and periods as model group. To get the livers ample and serum, the expression of DIO- I mRNA in liver and thyroid hormone level in serum were detected. Result Compared with control group, the expression of DIO- I mRNA in liver of model group was significantly decreased (P<0. 05 ) , and the TT3 , FT3 level in serum of model group were notably dropped ( P<0. 05 ) . Conclusion HDCP can result in the reduction of the expression of DIO-I mRNA in rat liver , and then the serum level of TT3 and FT3 are both dropped .

Key words: HDCP, DIO- I , qPCR, Thyroid hormone