关键词: 精神依赖药物, 海洛因, Bax, 小脑, 大鼠

Abstract: Objective To study the effects of psychotropic drug (heroin) on the expression of Bax gene in the cerebellar of addicted rats. Method An addictive rat model was used to establish with a dose-increasing method and the gene expression of Bax in the cerebellar cells was detected by ELISA. Result After injecting heroin for 7 days, the rats showed obvious withdrawal symptoms. The levels of Bax, Caspase-3, and Caspase-9 in cerebellar cells were increased 88.21%, 94.21%, and 87.24% respectively, which was significantly different compared with the control group (P<0.01). Conclusion The damage effect of psychoactive drugs(heroin) on brain tissue cells may be achieved by inducing the expression of cerebellar Bax gene and activating caspase.

Key words: psychotropic drugs, Heroin, Bax, Cerebellum, rats