关键词: 高脂血症, 动物模型, 食蟹猴

Abstract: Objective To establish Cynomolgus monkey model of hyperlipidemia. Method Cynomolgus were feed by high fat diet,the levels of total cholesterol(TC), high-density lipoprotein(HDL), low density lipoprotein (LDL), triglyceride(TG) of the Cynomolgus monkey were determined at 4, 8, 12, 18months for analyzing the trend of each paramaters above. Result When it was 4 months, the level of TC,HDL,LDL were higher significantly than that before feeding the high fat diet(P<0.01). When it was 8 months, the level of TG was higher sifnificantly than that before feeding the high diet(P<0.01). And the levels of TC, HDL, LDL and TG of model group were significantly different from that of the control group(P<0.01) at 8 months, 18 months. At this experiment, TC, HDL,LDL,TG all showed a increase trend, expecially the levels of TC and LDL much higher than the normal levels of Cynomolgus monkey. Conclusion Cynomolgus monkey of the model group has the feature of high total cholesterol and high low-density lipoprotein cholesterol, the method to establish Cynomolgus monkey model of experimental hyperlipidemia was feasible.

Key words: Hyperlipidemia, animal model, Cynomolgus monkey