关键词: GLP, SD大鼠, 指标

Abstract: Objective Establish the normal biological indicators of normal Sprague Dawley (SD) rats for long term toxicity test in barrier environment animal laboratory of center for safety evaluation of traditional Chinese medicine(GLP), to provide references for the future researchers. Method Breeding normally ten batches of normal SD rats in long term toxicity test, measured weight gains and food intakes once a week, measured organ indexes, blood and biochemical indicators at the end of 3, 6 months and recovery period. Result The result show that the food intakes of male SD rats were higher, increase linearly in body weights,higher than that in females, the organ indexes were declined in male rats. It showed that the growth and development,efficiency of feed utilization of male rats was faster than that in female rats. There were no significant changes in blood and biochemical indexes. Conclusion These normal data indicators can provide reference indexes for future GLP barrier environmental laboratory rat test.

Key words: GIP, SD rats, indicators